Episodes

Re-Founding Incumbents for the AI Era with Sequence Holdings Co-Founder and CEO Michael Lee

no-priors · Sep 24, 2026 · 42:44

Why Diffusion Will Win AI Inference with Inception Co-Founder and CEO Stefano Ermon

no-priors · Sep 18, 2026 · 38:13

Coinbase’s Everything Exchange: Agentic Finance, Stablecoins, and Tokenization with CEO Brian Armstrong

no-priors · Sep 10, 2026 · 45:09

Redefining Chip Architecture with Arm CEO Rene Haas

no-priors · Sep 3, 2026 · 37:06

Rethinking Legacy Data Infrastructure with Eon Co-Founders Ofir Ehrlich and Gonen Stein

no-priors · Aug 27, 2026 · 34:50

From Restoring Sight to Reimagining the Brain, with Max Hodak

no-priors · Aug 20, 2026 · 31:38

no-priors · Aug 13, 2026 · 46:07

no-priors · Aug 6, 2026 · 39:29

no-priors · Jul 31, 2026 · 34:29

no-priors · Jul 23, 2026 · 49:19

no-priors · Jul 9, 2026 · 41:04

no-priors · Jul 2, 2026 · 1:01:26

Really Big Test-Time Compute in AI Changes Benchmarks, Safety and Research with OpenAI Research Scientist Noam Brown

no-priors · Jun 26, 2026 · 36:18

Re-engineering the Semiconductor Supply Chain with Intel CEO Lip-Bu Tan

no-priors · Jun 18, 2026 · 44:59

no-priors · Jun 10, 2026 · 56:20

We Need An Ecosystem in AI, And Every Company Can Win A Place In It

no-priors · Jun 4, 2026 · 42:26

Building an AI Guardian for Enterprise with Onyx Security CEO Maxim Bar Kogan

no-priors · May 28, 2026 · 41:08

The Story Behind Cerebras’ $63 Billion IPO with Founder and CEO Andrew Feldman

no-priors · May 21, 2026 · 30:33

Pax Silica: Inside the Trump Administration’s Tech Strategy with US Under Secretary of State for Economic Affairs Jacob Helberg

no-priors · May 14, 2026 · 38:00

Amex Global Business Travel: The World’s First AI Take Private with Long Lake CEO Alexander Taubman

no-priors · May 11, 2026 · 22:00

Baseten CEO Tuhin Srivastava on the AI Inference Crunch, Custom Models, and Building the Inference Cloud

no-priors · May 1, 2026 · 42:57

SAP: Bringing the ‘Operating System’ of a Company into the AI Era with CTO Philipp Herzig

no-priors · Apr 23, 2026 · 45:44

Scaling Global Organizations in the Age of AI with ServiceNow Chairman and CEO Bill McDermott

no-priors · Apr 17, 2026 · 57:27

The Agentic Economy: How AI Agents Will Transform the Financial System with Circle Co-Founder and CEO Jeremy Allaire

no-priors · Apr 9, 2026 · 44:00

AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus

no-priors · Apr 3, 2026 · 29:25

Andrej Karpathy on Code Agents, AutoResearch, and the Loopy Era of AI

no-priors · Mar 20, 2026 · 1:06:31

From Coder to Manager: Navigating the Shift to Agentic Engineering with Notion Co-Founder Simon Last

no-priors · Mar 12, 2026 · 29:02

How Capital is Powering the AI Infrastructure Buildout with Magnetar Capital Managing Director Neil Tiwari

no-priors · Feb 26, 2026 · 36:04

From SaaS to AI-First: How Companies Are Reshaping Innovation

no-priors · Feb 19, 2026 · 40:41

Rivian’s Roadmap to AI Architecture and Autonomy with Founder and CEO RJ Scaringe

no-priors · Feb 12, 2026 · 31:46

Introducing 4D Creation Open Beta: NPCs, 4D Worlds, and the Future of Gaming with Roblox CEO Dave Baszucki

no-priors · Feb 5, 2026 · 43:44

Why Cryopreservation is No Longer Science Fiction with Until Co-founder and CEO Laura Deming

no-priors · Jan 29, 2026 · 30:47

No Priors Live: Building Durable Software in the AI Age with MongoDB President & CEO CJ Desai

no-priors · Jan 22, 2026 · 36:37

AI and the Future of Warfare with US Under Secretary of War Emil Michael

no-priors · Jan 15, 2026 · 44:30

NVIDIA’s Jensen Huang on Reasoning Models, Robotics, and Refuting the “AI Bubble” Narrative

no-priors · Jan 8, 2026 · 1:16:20

The 2026 AI Forecast: Foundation Models, IPOs, and Robotics with Sarah Guo and Elad Gil

no-priors · Dec 19, 2025 · 40:46

The Future of Voice AI: Agents, Dubbing, and Real-Time Translation with ElevenLabs Co-Founder Mati Staniszewski

no-priors · Dec 11, 2025 · 41:38

Scaling Legal AI and Building Next-Generation Law Firms with Harvey Co-Founder and President Gabe Pereyra

no-priors · Dec 5, 2025 · 44:17

Sunday Robotics: Scaling the Home Robot Revolution with Co-Founders Tony Zhao and Cheng Chi

no-priors · Nov 19, 2025 · 39:16

How AI Will Accelerate Breakthroughs in Biotechnology with Benchling CEO Sajith Wickramasekara

no-priors · Nov 13, 2025 · 48:13

Meet Snowflake Intelligence: A Personalized Enterprise Intelligence Agent with Sridhar Ramaswamy

no-priors · Nov 6, 2025 · 42:11

The Best of 2025 (So Far) with Sarah Guo and Elad Gil

no-priors · Oct 31, 2025 · 18:58

Reinventing the Developer Terminal with Warp Co-Founder and CEO Zach Lloyd

no-priors · Oct 23, 2025 · 27:18

Unlocking the Road to Energy Abundance with Base Power CEO and Co-Founder Zach Dell

no-priors · Oct 15, 2025 · 31:57

Humans&: Bridging IQ and EQ in Machine Learning with Eric Zelikman

no-priors · Oct 9, 2025 · 36:58

The Impact of AI, from Business Models to Cybersecurity, with Palo Alto Networks CEO Nikesh Arora

no-priors · Oct 4, 2025 · 58:21

Reinventing K-12 Education Using AI with Alpha School Principal Joe Liemandt

no-priors · Sep 25, 2025 · 1:01:49

AI Agents Talking to AI Agents: Reinventing Commerce with Decagon CEO Jesse Zhang

no-priors · Sep 18, 2025 · 31:22

Jared Kushner: BrainCo, Affinity Partners, and the Geopolitics of AI

no-priors · Sep 15, 2025 · 58:24

A New Operating System for Physicians with OpenEvidence Founder Daniel Nadler

no-priors · Sep 5, 2025 · 44:48

Reshaping America’s Economy for the Superintelligence Century with Jacob Helberg

no-priors · Aug 28, 2025 · 40:53

How Agentic AI is Transforming The Startup Landscape with Andrew Ng

no-priors · Aug 21, 2025 · 42:11

Chips, Neoclouds, and the Quest for AI Dominance with SemiAnalysis Founder and CEO Dylan Patel

no-priors · Aug 14, 2025 · 47:17

The Shifting Value of Content in the AI Age with Cloudflare CEO Matthew Prince

no-priors · Aug 7, 2025 · 45:16

America’s Plan to Dominate the Full AI Stack with Sriram Krishnan

no-priors · Jul 31, 2025 · 36:47

The Power of Quality Human Data with SurgeAI Founder and CEO Edwin Chen

no-priors · Jul 24, 2025 · 32:58

Asimov: Building An Omniscient RL Oracle with ReflectionAI’s Misha Laskin

no-priors · Jul 17, 2025 · 1:02:54

Why Platforms Win and Point Solutions Fail with Rippling CEO Parker Conrad

no-priors · Jul 10, 2025 · 44:43

Chai-2: The AI Model Accelerating Drug Discovery with Chai Discovery Co-Founders Jack Dent and Joshua Meier

no-priors · Jul 3, 2025 · 49:27

Meet AlphaEvolve: The Autonomous Agent That Discovers Algorithms Better Than Humans With Google DeepMind’s Pushmeet Kohli and Matej Balog

no-priors · Jun 26, 2025 · 42:08

The Operating System for Self Driving Cars (and Tanks, and Trucks...) With Qasar Younis and Peter Ludwig of Applied Intuition

no-priors · Jun 17, 2025 · 45:21

Will we have Superintelligence by 2028? With Anthropic’s Ben Mann

no-priors · Jun 12, 2025 · 41:25

Teaching AI to Understand the Physical World, with Dr. Fei-Fei Li of World Labs

no-priors · Jun 5, 2025 · 35:46

AI Consolidation, Biotech Opportunities, and World Models with Sarah and Elad

no-priors · May 29, 2025 · 25:13

AI is Making Enterprise Search Relevant, with Arvind Jain of Glean

no-priors · May 15, 2025 · 31:33

Gaming as the Future of Education with Duolingo CEO Luis von Ahn

no-priors · May 8, 2025 · 32:14

O3 and the Next Leap in Reasoning with OpenAI’s Eric Mitchell and Brandon McKinzie

no-priors · May 1, 2025 · 38:10

Inside Deep Research with Isa Fulford: Building the Future of AI Agents

no-priors · Apr 24, 2025 · 30:45

Predicting the Earth with Josh Goldman: How KoBold Uses AI to Find Critical Minerals

no-priors · Apr 17, 2025 · 40:53

From Job Displacement to AI Trainers, Brendan Foody on Work in the AI Age

no-priors · Apr 10, 2025 · 41:52

Public Markets, Image Gen, and Specialized Models, with Sarah and Elad

no-priors · Apr 3, 2025 · 27:44

Conversations Are the Source of Truth in Healthcare with Abridge CEO Shiv Rao

no-priors · Mar 27, 2025 · 38:42

The Robotics Revolution, with Physical Intelligence’s Cofounder Chelsea Finn

no-priors · Mar 20, 2025 · 35:14

Copilot, Agent Mode, and the New World of Dev Tools with GitHub’s CEO Thomas Dohmke

no-priors · Mar 13, 2025 · 50:34

National Security Strategy and AI Evals on the Eve of Superintelligence with Dan Hendrycks

no-priors · Mar 5, 2025 · 36:24

Building the Platform for Scientific Breakthrough, with Noubar Afeyan of Moderna and Flagship Pioneering

no-priors · Feb 27, 2025 · 40:32

Virtual Cell Models, Tahoe-100 and Data for AI-in-Bio with Vevo Therapeutics and the Arc Institute

no-priors · Feb 25, 2025 · 57:40

Building Hard Tech in Hard Markets: Kyle Vogt on Cruise, Twitch, and The Bot Company

no-priors · Feb 20, 2025 · 38:14

How Harvey AI is Changing the Legal Industry with Winston Weinberg

no-priors · Feb 14, 2025 · 49:35

DeepSeek, Deep Research, and 2025 Predictions with Sarah and Elad

no-priors · Feb 7, 2025 · 22:32

Rick Caruso on LA’s Wildfires, Policy Failures, and the Path Forward

no-priors · Jan 30, 2025 · 27:11

What Can We Do About Wildfires? With Convective Capital’s Bill Clerico

no-priors · Jan 23, 2025 · 37:57

How AI Agents Are Transforming Customer Support, with Decagon’s Jesse Zhang

no-priors · Jan 16, 2025 · 30:09

Erik Bernhardsson on Creating Tools That Make AI Feel Effortless

no-priors · Jan 9, 2025 · 23:36

The Best of 2024 with Sarah Guo and Elad Gil

no-priors · Dec 26, 2024 · 27:06

Revolutionizing Customer Success with Agency’s Elias Torres

no-priors · Dec 19, 2024 · 31:18

How Diamond Cooling Could Power the Future of AI, with Akash Systems

no-priors · Dec 12, 2024 · 42:21

Bolt’s Eric Simons on Enabling Everyone to Generate Websites with AI

no-priors · Dec 5, 2024 · 38:17

Model Plateaus and Enterprise AI Adoption with Cohere's Aidan Gomez

no-priors · Nov 21, 2024 · 44:15

AI and the Future of Math, with DeepMind’s AlphaProof Team

no-priors · Nov 14, 2024 · 39:21

NVIDIA's Jensen Huang on AI Chip Design, Scaling Data Centers, and his 10-Year Bets

no-priors · Nov 7, 2024 · 36:53

Forecasting the Future with Kalshi: America’s First Regulated Prediction Market

no-priors · Oct 31, 2024 · 35:36

Waymo’s Journey to Full Autonomy: AI Breakthroughs, Safety, and Scaling

no-priors · Oct 24, 2024 · 44:30

Gaming, Nobel Prizes and At-Risk Businesses in the AI Era

no-priors · Oct 17, 2024 · 29:29

Launching AI products with Braintrust’s CEO Ankur Goyal

no-priors · Oct 8, 2024 · 38:28

The Sheriff of Silicon Valley: Lina Khan’s FTC agenda for M&A, AI Acquisitions, and Non-Competes

no-priors · Oct 3, 2024 · 26:08

Using AI to evaluate employee performance with Rippling’s COO Matt MacInnis

no-priors · Sep 25, 2024 · 31:28

Transforming Customer Service through Company Agents, with Sierra’s Bret Taylor

no-priors · Sep 19, 2024 · 48:30

Future of LLM Markets, Consolidation, and Small Models with Sarah and Elad

no-priors · Sep 12, 2024 · 26:28

The Road to Autonomous Intelligence with Andrej Karpathy

no-priors · Sep 5, 2024 · 44:16

Building toward a bright post-AGI future with Eric Steinberger from Magic.dev

no-priors · Aug 30, 2024 · 37:49

Cloud Strategy in the AI Era with Matt Garman, CEO of AWS

no-priors · Aug 29, 2024 · 42:58

The marketplace for AI compute with Jared Quincy Davis from Foundry

no-priors · Aug 22, 2024 · 43:12

How AI can help build smarter systems for every team with Eric Glyman and Karim Atiyeh of Ramp

no-priors · Aug 15, 2024 · 48:50

Innovating Spend Management through AI with Pedro Franceschi from Brex

no-priors · Aug 8, 2024 · 33:39

Google DeepMind's Vision for AI, Search and Gemini with Oriol Vinyals from Google DeepMind

no-priors · Aug 1, 2024 · 46:08

Low-Code in the Age of AI and Going Enterprise, with Howie Liu from Airtable

no-priors · Jul 25, 2024 · 41:25

How AI is opening up new markets and impacting the startup status quo with Sarah Guo and Elad Gil

no-priors · Jul 18, 2024 · 29:12

The Best of 2024 (so far) with Sarah Guo and Elad Gil

no-priors · Jul 11, 2024 · 25:56

State Space Models and Real-time Intelligence with Karan Goel and Albert Gu from Cartesia

no-priors · Jun 27, 2024 · 34:08

Can AI replace the camera? with Joshua Xu from HeyGen

no-priors · Jun 20, 2024 · 27:26

How the ARC Prize is democratizing the race to AGI with Mike Knoop from Zapier

no-priors · Jun 11, 2024 · 26:03

The evolution and promise of RAG architecture with Tengyu Ma from Voyage AI

no-priors · Jun 6, 2024 · 36:20

How YC fosters AI Innovation with Garry Tan

no-priors · May 23, 2024 · 39:59

The Data Foundry for AI with Alexandr Wang from Scale

no-priors · May 22, 2024 · 39:00

Music consumers are becoming the creators with Suno CEO Mikey Shulman

no-priors · May 16, 2024 · 30:26

Context windows, computer constraints, and energy consumption with Sarah and Elad

no-priors · May 9, 2024 · 29:10

Cognition’s Scott Wu on how Devin, the AI software engineer, will work for you

no-priors · May 2, 2024 · 29:28

OpenAI’s Sora team thinks we’ve only seen the "GPT-1 of video models"

no-priors · Apr 25, 2024 · 31:24

The Future of AI Artistry with Suhail Doshi from Playground AI

no-priors · Apr 18, 2024 · 24:31

Hyperscaler strategy in AI, the application landscape heats up, and what we know now about agents with Sarah and Elad

no-priors · Apr 11, 2024 · 26:12

The argument for humanoid AI robots with Brett Adcock from Figure

no-priors · Apr 4, 2024 · 38:13

Open sourcing AI app development with Harrison Chase from LangChain

no-priors · Mar 28, 2024 · 27:32

Speed will win the AI computing battle with Tuhin Srivastava from Baseten

no-priors · Mar 21, 2024 · 38:32

Designing the Future: Dylan Field on AI, Collaboration, and Independence

no-priors · Mar 14, 2024 · 36:32

Big tech earnings and the current AI debates, with Sarah Guo and Elad Gil

no-priors · Mar 7, 2024 · 42:14

Competition makes for better chip design with AMD CTO Mark Papermaster

no-priors · Feb 29, 2024 · 39:08

Improving search with RAG architecture with Pinecone CEO Edo Liberty

no-priors · Feb 22, 2024 · 31:28

RAG is the key for smarter productivity tools with Notion CEO Ivan Zhao

no-priors · Feb 15, 2024 · 42:07

Build AI products at on-AI companies with Emily Glassberg Sands from Stripe

no-priors · Feb 8, 2024 · 39:24

The Copilot for Ecommerce with Shopify VP of Core Product Glen Coates

no-priors · Jan 31, 2024 · 39:08

Building the factories of the future with Covariant CEO Peter Chen

no-priors · Jan 25, 2024 · 40:57

Coding in Collaboration with AI with Sourcegraph CTO Beyang Liu

no-priors · Jan 18, 2024 · 46:42

A No Priors clip show: the best of 2023

no-priors · Jan 11, 2024 · 19:21

The case for AI optimism

no-priors · Dec 21, 2023 · 47:13

How AI can help small businesses

no-priors · Dec 14, 2023 · 39:35

AI is the new enterprise UI with Clara Shih, CEO Salesforce AI

no-priors · Dec 7, 2023 · 27:14

Open AI leadership shuffle, new diffusion models, and starting the cult of Q*

no-priors · Nov 30, 2023 · 26:01

AI Agents That Reason and Code with Imbue Co-Founders Kanjun Qiu and Josh Albrecht

no-priors · Nov 16, 2023 · 32:48

Mistral 7B and the Open Source Revolution With Arthur Mensch, CEO Mistral AI

no-priors · Nov 9, 2023 · 32:57

What is Digital Life? with OpenAI Co-Founder & Chief Scientist Ilya Sutskever

no-priors · Nov 2, 2023 · 41:58

AI Threats & Opportunities in Cyber Security With Material Security Co-Founder Ryan Noon

no-priors · Oct 26, 2023 · 36:22

What Google Cloud Can Teach Enterprises Developing & Rolling Out AI Tools, With Kawal Gandhi

no-priors · Oct 23, 2023 · 32:37

From App to Suite to Platform, with HubSpot's Co-Founder Brian Halligan

no-priors · Oct 12, 2023 · 43:07

Model Quality, Fine Tuning & Meta Sponsoring Open Source Ecosystem

no-priors · Oct 9, 2023 · 23:53

If DNA is Code, Can AI Help Write It? Scaling Cell Programming and Synthetic Biology, with Ginkgo Bioworks Co-founder and CEO Jason Kelly

no-priors · Sep 28, 2023 · 37:00

How Replit’s AI Tools are Changing Software Development with Co-founder and CEO Amjad Masad

no-priors · Sep 21, 2023 · 29:37

The Intersection of AI and Blockchain, with Transformers author and NEAR founder Illia Polosukhin

no-priors · Sep 15, 2023 · 42:24

The World’s Largest AI Processor with Cerebras CEO Andrew Feldman

no-priors · Sep 7, 2023 · 30:03

AI Superpowers for Frontend Developers, with Vercel Founder/CEO Guillermo Rauch

no-priors · Aug 31, 2023 · 38:13

AI-Powered Biological Software with Jakob Uszkoreit, CEO of Inceptive

no-priors · Aug 24, 2023 · 35:23

The AI Tutor For Every Child and the Next Frontier of Education, From Khan Academy’s Creator Sal Khan

no-priors · Aug 17, 2023 · 47:42

Listener Q&A: 2024 Tech Market Predictions, Long Term Implications of Today’s GPU Crunch, and Will AI Agents Bring Us Happiness?

no-priors · Aug 10, 2023 · 24:01

Eradicating Machine Learning Pain Points with Weights & Biases CEO Lukas Biewald

no-priors · Aug 3, 2023 · 43:44

How Palantir’s AI Bet is Revolutionizing Defense and Beyond, with CTO Shyam Sankar

no-priors · Jul 27, 2023 · 39:45

The Timeline for Realistic 4-D: Devi Parikh from Meta on Research Hurdles for Generative AI in Video and Multimodality

no-priors · Jul 20, 2023 · 39:50

Bringing AI to the Data Cloud, with Snowflake's CEO Frank Slootman

no-priors · Jun 29, 2023 · 51:52

What's for Dinner? AI-Driven Commerce with Instacart CEO Fidji Simo

no-priors · Jun 22, 2023 · 40:07

What happens to Observability If Code is AI-Generated? The Potential for AI in DevOps, with Datadog Co-founder/CEO Olivier Pomel

no-priors · Jun 15, 2023 · 44:48

Listener Q&A: AI Misconceptions, The Reality of Regulation, Infinite Context, Incumbent AI Execution and Startup Ideas

no-priors · Jun 8, 2023 · 35:27

AI & Defense Technology with Anduril CEO Brian Schimpf

no-priors · Jun 1, 2023 · 50:36

Going Full Send on AI, and the (Positive) Impact of AI on Jobs, with Kevin Scott, CTO of Microsoft

no-priors · May 24, 2023 · 55:26

The AI Will See You Now: Exploring Biomedical AI and Google’s Med-PaLM2 With Karan Singhal

no-priors · May 18, 2023 · 42:48

Will Everyone Have a Personal AI? With Mustafa Suleyman, Founder of DeepMind and Inflection

no-priors · May 11, 2023 · 52:25

Personalizing AI Models with Kelvin Guu, Senior Staff Research Scientist, Google Brain

no-priors · May 4, 2023 · 40:19

Listener Q&A: AI Investment Hype, Foundation Models, Regulation, Opportunity Areas, and More

no-priors · Apr 27, 2023 · 34:00

The Computing Platform Underlying AI, with Jensen Huang, Founder & CEO of NVIDIA

no-priors · Apr 20, 2023 · 45:07

Your AI Friends Have Awoken, With Noam Shazeer

no-priors · Apr 13, 2023 · 30:20

The Future is Small Models, with Matei Zaharia, CTO of Databricks

no-priors · Apr 6, 2023 · 39:29

What’s Beyond GitHub Copilot? With Copilot's Chief Architect and founder of Minion.AI Alex Graveley

no-priors · Mar 30, 2023 · 36:21

How do we go from search engines to answer engines? With Perplexity AI’s Aravind Srinivas and Denis Yarats

no-priors · Mar 23, 2023 · 38:49

What is the future of search? With Neeva’s Sridhar Ramaswamy

no-priors · Mar 16, 2023 · 36:04

What is the role of academia in modern AI research? With Stanford Professor Dr. Percy Liang

no-priors · Mar 9, 2023 · 46:37

How AI can make drug discovery fail less, with Daphne Koller from Insitro

no-priors · Mar 2, 2023 · 46:06

Why the Future of Machine Learning is Open Source with Huggingface’s Clem Delangue

no-priors · Feb 23, 2023 · 31:39

Founder Stories: What’s behind the largest commercial autonomous system on earth? With Zipline’s Keller Rinaudo Cliffton

no-priors · Feb 20, 2023 · 46:17

How can we make sure that everyone has access to AI? Can small models outperform large models? With Stability AI’s Emad Mostaque

no-priors · Feb 16, 2023 · 46:06

What does AI-powered content creation look like? with Runway ML’s Cristobal Valenzuela

no-priors · Feb 9, 2023 · 46:57

This is “No Priors”

no-priors · Feb 2, 2023 · 1:59

The bot Cicero can collaborate, scheme and build trust with humans. What does this mean for the next frontier of AI? With Noam Brown, Research Scientist at Meta

no-priors · Feb 2, 2023 · 58:40